MELANOMA TABLE OF CONTENTS EXPERT PERSPECTIVES ................................ 4 Evaluating Melanoma-specific Survival Stratification and Survival Benefit of Gene Testing in Patients with Melanoma ORIGINAL RESEARCH ................................... 5 A Prospective, Multicenter Analysis of Recurrence-free Survival After Sentinel Lymph Node Biopsy Decisions Influenced by the 31-GEP MEETING HIGHLIGHTS ................................. 9 ASCO 2025 Annual Meeting— Summaries of Abstracts from the Meeting CASE STUDY SPOTLIGHT ........................... 12 A Presentation and Discussion of Notable Cases of Melanoma RESEARCH SUMMARY .............................. 14 Comparing Two Gene Expression Profile Tests to Standard of Care for Identifying Patients with Cutaneous Melanoma at Low Risk of Sentinel Lymph Node Positivity JOURNAL WATCH ...................................... 15 Highlights of Recently Published Research in Melanoma NEWS & TRENDS........................................ 17 Exploring Melanoma Updates in the Media DIGITAL RESOURCE CENTER.................... 19 Resources and Events in Melanoma Research and Practice JOURNAL STAFF Managing Editor Julia E. Eckert Managing Editor Austin K. Vitelli Associate Editor Amanda Tolvaisa Associate Editor Gannon R. Vitelli Assistant Editor Diana Dopheide BUSINESS STAFF Director Joseph Scullin Director E. Patrick Scullin Director Emily A. Scullin Chief Medical Officer Giselle J. Geddes, MD Senior Vice President Joseph J. Morris Associate Director of Business Development Courtney McKinney Associate Director of Business Development Morgan Rinnier Associate Director of Business Development Dana Buttenbaum Data Analyst Andrew Daly Project Manager Kim Hooven Partner Patrick D. Scullin ©2025 Matrix Medical Communications. All rights reserved. This journal is a topic-specific publication that compiles and summarizes peer-reviewed, previously published content for physicians with an interest in breast cancer management. Opinions expressed by authors, contributors, and advertisers are their own and not necessarily those of Matrix Medical Communications, the editorial staff, or any member of the company’s editorial advisory boards. Matrix Medical Communications is not responsible for accuracy of dosages given in the articles printed herein. The appearance of advertisements in this journal is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality, or safety. Matrix Medical Communications disclaims responsibility for any injury to persons or property resulting from any ideas or products referred to in the articles or advertisements. Matrix Medical Communications, LLC 1595 Paoli Pike • Ste 103 • West Chester, PA 19380 • info@matrixmedcom.com Hot Topics in Melanoma [July 2025] 3