® RISK IDENTIFIED EVERY MELANOMA IS UNIQUE. Q SO IS ITS RISK. DecisionDx-Melanoma provides p a personalized p risk assessment f sentinel lymph y y and recurrence/metastasis. for node positivity i3 i31-ROR O i31-SLNB INDIVIDUAL RISK I SK OF O RECURRENCE CU CE Integrates clinicopathologic I li i h l i f (CP) factors with GEP to p p p ˚ c provide patient-speci risk of recurrence including r g Ǽ melanoma-speci ˚ c survival, d sta t metastasis-free etastas s ee distant survival, s , and recurrence-f free survival. C CP factors include: i c ude: • • • • • • Ulceration U B l Breslow thickness hi k s A Age Mi i rate Mitotic S SLN status Tu o location Tumor ocat o INDIVIDUAL RISK OF SENTINEL LYMPH NODE POSITIVITY Integrates CP factors to provide personalized results for a patient's likelihood of a positive sentinel lymph node. CP factors include: • • • • Ulceration Breslow thickness Age Mitotic rate Learn more about how to incorporate GEP testing at your institution. 2 H t To Ho o pi p i c cs s i n M Me e l la a n no o m ma a [ J Ju u ly l y 2 02 0 2 5 5] ] ©2025 Castle Biosciences Inc, CB-051v2-062025
Journal of Clinical and Aesthetic Dermatology Hot Topics in Melanoma July 2025: Page 2
