2025-10-31 14:13:29
Presenters: Watchmaker J,1 Nelson DB2 Affiliations: 1Southwest Skin Specialists, Scottsdale, AZ; 2skinbetter science, Phoenix, AZ
Background: Integrating skincare products before and after laser resurfacing procedures helps support skin quality and patient outcomes. Plant adaptogens are rich phytochemicals that promote homeostasis helping to increase resistance to stress, mitigate inflammation, and prevent premature aging.1 A serum containing plant adaptogens demonstrated significant improvements from baseline in global skin quality in subjects with mild-to-severe facial photodamage over 12 weeks.2
Objectives: Evaluate the safety and efficacy of a serum containing plant adaptogens (MYS) compared to a moisturizer pre- and post-laser treatment.
Design: A single-center, investigator blinded, split-face controlled study enrolled females 35-65 years of age with mild-to-moderate photodamaged skin (score of 3-6) based on a 10-point grading scale including at least two visible signs of photodamage: erythema, prominent/ enlarged pores, dull/ sallow skin tone, rough skin texture, and uneven pigmentation. Subjects were randomly assigned to apply MYS to the right or left side of their face followed by a moisturizing lotion (ML), twice-daily for two weeks; on the opposite side of their face, subjects applied the ML only, twice-daily for two weeks. Following a single fractional laser treatment (Fraxel® 1927, 10 mJ, 35-40%, 8 passes), subjects applied products per initial assignment through Day 10 (up to 2 additional applications of ML only to either side of their face was permitted). Investigator and subject assessed tolerability occurred immediately post-procedure and on Days 1, 2, 4, 7, and 10 using a 4-point grading scale (0=None to 3=Severe). Investigator assessment of global skin healing utilized a 5-point grading scale (0=Poor to 4= Excellent) on Days 1, 2, 4, 7, and 10. Global skin quality was calculated utilizing our Global Skin Quality Index (total sum of scores combined for erythema, dullness, texture, pore size and uneven pigmentation using 6-point grading scales [0=None to 5=Very Serve]) based on investigator assessments at Baseline, Week 2 (pre-procedure), and Day 10 (post-procedure). Adverse Events (AEs) were captured throughout the study.
Results: Fifteen females completed the study (52 years, mean age). All AEs were temporary and procedurally related. Subjects reported significantly less dryness/flaking on the MYS side of their face vs. the ML side on Day 4 (p=.04). According to investigator assessments, significantly less dryness occurred on the MYS side vs. ML side on Days 1 and 2 (p=.05 and p=.001, respectively). Less erythema occurred on the MYS side vs. ML side (29% vs. 17%) on Day 2. Significant mean improvements occurred in global skin healing on the MYS side vs. ML side occurred on Days 1, 2, and 4 (p=.04, p=.003, p=.003, respectively). No significant differences occurred at Days 7 and 10. Significant mean improvements in global skin quality occurred on the MYS side vs. ML side at Week 2 (pre-procedure) and Day 10 (postprocedure [p=.03 and p=.001, respectively]).
Conclusion: Integrating the use of a serum containing plant adaptogens before and after a fractional laser treatment demonstrated significant mean improvements in global skin healing compared to a moisturizer alone on Days 1, 2, and 4 post-procedure, and resulted in significant mean improvements in global skin quality pre- and post-procedure.
Disclosures: Dr. Watchmaker was the study investigator, and Ms. Nelson is an employee of skinbetter science.
Funding: This study was sponsored by skinbetter science, LLC.
References:
1 Pomatto LCD, Davies KJA. The role of declining adaptive homeostasis in ageing. J Physiol. 2017;595(24):7275-7309.
2 Draelos ZD, Grimes PE, Watchmaker J, Nelson DB. A multi-center trial evaluating a serum comprised of plant-based adaptogens targeting skin quality. J Clin Aesthet Dermatol. 2024;17(2):15-19.
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