2025-10-29 08:57:40
Presenters: Blyumin-Karasik M, Colon J, Gaer S, Vigil I, Nguyen S, Rosen J
Background: Laser resurfacing treatments such as UltraClear®, CO2RE®, and GentleMax Pro® have revolutionized dermatological procedures by improving skin texture, tone, and overall quality. However, optimal periprocedural management remains crucial to minimize side effects, support healing, and achieve the best cosmetic outcomes. Hypochlorous acid (HOCl), a naturally occurring oxidant with anti-inflammatory and antimicrobial properties, has shown success in supporting and accelerating wound healing and reducing post-procedural scarring. This case series investigates the use of stabilized HOCl mist in the peri-procedural care of patients undergoing laser resurfacing.
Methods: Ten patients underwent treatment with UltraClear®, CO2RE®, and/ or GentleMax Pro® laser with peri-procedural application of 0.02% HOCl mist. The mist was applied immediately before and after the procedure, with patients instructed to continue application twice daily for one week post-treatment. Follow-up assessments at 1 to 3 weeks and 1 to 3 months post-procedure included clinical photography, tolerability evaluation, and aesthetic outcome assessment. Variables analyzed included Clinician Erythema Assessment (CEA), 4-point Edema Scale, Investigator Global Assessment of Pigmentation Scale (IPA), and Global Aesthetic Improvement scores using Friedman and Wilcoxon signed-rank tests, with significance set at p < 0.05.
Results: Use of HOCl mist was associated with accelerated recovery, including a noticeable reduction in erythema and pigmentation. Statistically significant improvements were observed in CEA (p=0.007) and IPA (p=0.012) scores, indicating reduced clinical severity and pigment alteration. Edema and GAIS scores showed no statistically significant change.
Discussion: Findings suggest that stabilized HOCl mist is well-tolerated and may aid in postprocedural recovery by minimizing common side effects and reducing discomfort. Patients reported improved skin appearance and satisfaction with outcomes.
Conclusion: This case series supports the potential role of stabilized HOCl mist as a beneficial adjunct in post-laser skincare, contributing to faster healing, reduced inflammation, and enhanced cosmetic results.
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