2025-10-29 09:16:36
Presenters: Blyumin-Karasik, M, Colon J, Karasik D, Nguyen S, Woolery-Lloyd H, Lain E
Background: Topical adaptogens are emerging bioactive skincare ingredients that enhance skin resilience by mitigating intrinsic and extrinsic stressors. Although adaptogens are primarily botanicals that have demonstrated dermatologic potential, a standardized system to classify and identify their mechanisms of action is lacking.
Methods: A systematic review was conducted using PubMed, OVID, and Cochrane databases to identify studies from the last 20 years involving topically applied botanical adaptogens. Eligible studies included in vitro, in vivo, or human trials designating compounds as adaptogens. From 643 screened articles, 12 met the inclusion criteria for detailed analysis.
Results: A total of 29 botanicals were identified as topical adaptogens. These compounds demonstrated multi-targeting and homeostatic effects, including antimicrobial, antioxidant activity, immune modulation, hormonal regulation, enhancement of skin barrier function, and optimization of the regenerative function. The authors developed a comprehensive MOA-based classification system to evaluate adaptogens’ safety, efficacy, and adaptogenic activity in skin.
Conclusion: This study identifies 29 topical adaptogens and introduces a novel classification system based on their mechanisms of action. By defining criteria for topical adaptogenic activity, this system offers a foundational framework for evaluating and advancing cosmeceutical ingredients in dermatology. Further studies are warranted to validate additional adaptogenic agents and explore their applications in skin health and aesthetics.
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