2025-10-29 09:11:17
Presenters: Moradi A,1 Draelos ZD,2 Guiotto A,3 Pecorelli A,3 Smathers A4
Affiliations: 1Moradi M.D., Vista, CA; 2Dermatology Consulting Services, PLLC, High Point, NC; 3Dept. of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy; 4skinbetter science, a Dermatological Beauty Brand of L’Oréal USA, Inc.
Background: Estrogen depletion impacts the skin through decreased production of types I and III collagen and elastin fibers, a diminished rate of cell renewal, impaired ability to retain moisture, and disruption to the natural barrier function.
Objectives: Evaluate histological changes from skin biopsies obtained from peri- and post-menopausal females using an enhanced serum containing plant adaptogens (MYS-EDS) at baseline and 16 weeks.
Methods: Volunteers with menopause-related visible skin changes who were participating in a multi-center, open-label trial agreed to have skin biopsies obtained at baseline and 16 weeks from unexposed skin of the volar upper arm (VUA; chronologic aging) and exposed skin from the dorsal forearm (DF; photoaging). Biopsies were evaluated for collagen and elastin (Collagen I, Collagen III, Elastin, MMP-2, MMP-9), and hydration (Claudin I).
Results: Skin biopsies were obtained from ten (n=10) subjects. Compared to baseline, at 16 weeks there were improvements in strength and elasticity of skin, hydration, and skin barrier support as shown by increases in Elastin (DF,+92% [p<.05], VUA, +107% [p<.005]); Collagen I (DF, +21%, [ns]; VUA, +26% [p<.05]); Collagen III (DF, +38%, VUA, +93% [all, p<.05]); and Claudin I (DF, +36% [p<.005], VUA, +59% [p<.05]); as well as reductions in MMP-2 after 16 weeks (DF, -30% [p<.05]; VUA, -37% [p<.005]); and MMP-9 (DF, -13% [ns], VUA, -43% [p<.005]).
Conclusion: Twice-daily use of MYS-EDS in peri- and post-menopausal subjects demonstrated significant histological changes from baseline over 16 weeks confirming an increase in collagen and elastin in both photoaged and chronologically aged skin.
Disclosures: AS is an employee of skinbetter science.
Funding: This study was sponsored by skinbetter science, a Dermatological Beauty Brand of L’Oréal USA, Inc.
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