2025-10-29 08:48:08
Presenters: Dimmers F,1 Marini A,1 Krutmann J,1 Wriedt S,2 Dryer L3
Affiliations: 1Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; 2QMS Medicosmetics GmbH, Teningen, Germany; 3Skin Sage Advisors, LLC, Conroe, TX
Background: Traffic-related air pollution such as diesel exhaust particles (DEP), is increasingly recognized as a driver of extrinsic skin aging and pigmentation disorders. This study aimed to assess the protective efficacy of a topical Even Tone Serum, with or without adjunct oxygen application, against DEP-induced skin pigmentation and oxidative stress.
Methods: This monocenter, interventional study enrolled 41 healthy adults (Fitzpatrick skin types I–IV). Subjects received daily applications of QMS Even Tone Serum, QMS Oxygen Applicator, or a combination thereof over five marked 5×5 cm areas on the back for 11 days. A modified Düsseldorf Air Pollution Patch Test (DAPP) was used to simulate topical DEP exposure, followed by evaluation of pigmentation changes via Individual Typology Angle (ITA°) and melanin index (DSM III ColorMeter), and antioxidant levels via reflection spectroscopy. Control areas received phosphate-buffered saline (PBS) or DEP only. The primary endpoints were changes in pigmentation and antioxidant status post-treatment and DEP exposure.
Results: DEP exposure led to a significant decrease in ITA° (increased pigmentation), particularly in untreated and Oxygen-only fields (mean ΔITA° −7.19 and −7.66, respectively). In contrast, treatment with Even Tone Serum (ΔITA° −2.49) or the combined Serum + Oxygen (ΔITA° −2.36) significantly attenuated pigmentation compared to DEP-only sites (p < 0.05). Antioxidant levels were better preserved in serum-treated sites.
Conclusion: The QMS Even Tone Serum, both alone and in combination with oxygen application, demonstrated significant protective effects against DEP-induced pigmentation and oxidative stress. These findings support its potential utility as a topical defense strategy against pollution-related skin damage.
Disclosures: SW is an employee of QMS Medicocosmetics.
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