2025-10-29 08:35:04
Presenters: DiNatale L,1 Santhanam U,2 Zhao X,3 Wang S,3 Zhong Y,3 Saliou C2
Affiliations: 1La Mer Max Huber Research Laboratories, Melville, NY; 2Research Laboratories, Estee Lauder Companies, Melville, NY; 3APAC Innovation lab, the Estee Lauder Companies, Shanghai, PR China
Background: The popularity of non-surgical cosmetic dermatologic facial procedures continue to rise due to their satisfying results with minimal downtime. The use of a standard-of-care moisturizer following such procedures is generally accepted as a necessary step to maintain skin hydration and aid in recovery from procedures. Advanced cosmetic products that contain bioactive ingredients can potentially enhance not just recovery, but post procedure outcomes as compared to ordinary moisturizers.
A complex of three marine sourced extracts, consisting of microcondensates of totipotent cells isolated from Crithmum maritimum, a supercritical CO2 wax extract of C. maritimum, and Laminaria digitata extract, hereinafter referred to as the marine complex (MC), was developed with the aim of offering retinol-like benefits. A ferment of the sea kelp Macrocystis pyrifera (MPF), has been previously demonstrated to provide significant antioxidant, anti-inflammatory and skin barrier benefits.
Objective: A topical formulation containing MC+MPF was developed [TM=Test Material] and evaluated in a split-face comparison versus a plain moisturizer [C=Control] following a full-face radiofrequency (RF) skin tightening procedure. Because collagen rebuilding and tissue remodeling continues for a period of weeks following RF procedures, the effects post procedure of TM versus C were tracked for 12 weeks.
Methods: An IRB approved randomized controlled clinical trial was conducted on n=33 female participants. Selected subjects exhibited mild to moderate appearance of photoaged skin. Following their consent, participants underwent an RF facial skin tightening procedure by a certified clinician. Starting one hour after the RF procedure, subjects applied equal amounts of TM and C to randomly assigned sides of the face and continued to apply twice daily for 12 weeks. Assessment of skin condition was conducted by expert clinical graders prior to the RF procedure and at 2, 4, 8, and 12 weeks after RF-procedure. Additionally, different imaging systems such as two-photon microscopy, 3D imaging for skin contour and PRIMOS for skin texture analysis were included in the evaluations.
Results: The RF treatment with the Control moisturizer provided statistically significant improvement from baseline in Crows Feet Wrinkles, Marionette Lines, Appearance of Nasolabial Fold, Facial Sagging as well as Texture, Tone and Evenness. Compared to the Control, the use of the Test Material following the RF procedure was found to significantly enhance the improvement of crows feet wrinkles, marionette lines, appearance of nasolabial fold, facial sagging while providing equivalent benefit for texture, tone and evenness.
Conclusion: These results demonstrate that a bioactive topical cream containing MC+MPF was shown to be more effective compared to a control moisturizer for enhancing skin appearance following RF skin tightening procedure.
Disclosures: The authors declare that all authors are employees of The Estée Lauder Companies and have no other conflicts of interest to disclose.
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