2025-10-29 08:26:43
Presenters: Konisky H,1 Bowe WP,2 Yang P,2 Jallorina A,1 Kobets K1
Affiliations: 1Montefiore Einstein, Bronx, NY, 2Dr. Whitney Bowe Beauty, Greenwich, CT
Background: Loss of collagen, elastin, and glycosaminoglycans in aging skin contributes to a reduction in both hydration and extracellular matrix integrity, resulting in sagging, loss of elasticity, fine lines, wrinkles, and a decrease in firmness alongside alterations in skin texture. Certain energy-based devices and injectable procedures performed in-office can stimulate regenerative changes in the dermal layer and even reverse or improve these age-related changes. While these procedures are recognized for reversing signs of skin aging via a wound healing response, current post procedure skincare protocols may not optimize skin recovery post procedure, nor fully optimize ultimate outcomes post-procedure. There is a growing demand for topical interventions that not only can work independently of these procedural interventions to improve these visible signs of aging but are also formulated and clinically tested to support skin recovery post-procedure.
Objective: To assess the efficacy and tolerability of a multi-peptide serum (DWB-P46) in two separate settings: (1) a 12-week clinical study measuring anti-aging benefits and skin hydration when used without an associated procedure, and (2) a real-world, in-office use case following dermatologic procedures to evaluate post-procedure recovery support.
Methods: Two efficacy studies, one safety assessment, and one tolerability evaluation were conducted. In a single-center, 12-week study, 25 healthy female participants (ages 42–67; 48% sensitive skin; Fitzpatrick I–IV) applied DWB-P46 twice daily after a seven-day washout. Clinical grading was performed at baseline, immediately post-application (5–15 minutes), Week 1, and Week 12 to assess facial fine lines/wrinkles, sagging, firmness, elasticity, texture (visual), smoothness (tactile), plumpness, brightness, and overall healthy appearance. Corneometer® measured skin hydration at baseline and immediately post-application. Subjects completed Self-Perception Questionnaires throughout. In a separate four-week in-office study, 15 female participants (ages 37–71; Fitzpatrick I–III) applied DWB-P46 immediately after and the night following their procedure, then continued with twice daily application post-procedure (including microneedling, nonablative fractional laser resurfacing, ultrasound therapy, radiofrequency microneedling therapy, HA injectable biostimulatory PLLA fillers, or superficial chemical peel). SPQ’s were collected throughout the study. Safety was supported by a 40-day Repeat Insult Patch Test (n=107; ages 18-64; 50% sensitive skin) and tolerability by a 4-week repeated occlusive patch study (n=15; ages 27–55) assessing dermal irritation and follicular response.
Results: Statistically significant improvements (p < 0.01) were observed in all clinically graded parameters by Week 12 in the 12-week study (n=25), including reductions in fine lines and wrinkles, increased skin firmness and elasticity, enhanced texture and smoothness, and improved plumpness and brightness. Hydration levels measured by Corneometer® increased significantly immediately post-application (p < 0.01).
In the four-week post-procedure study (n=15), DWB-P46 provided effective recovery support by enhancing and expediting skin healing, with patients reporting reduced redness, increased comfort, and improved skin resilience during recovery as compared to prior procedures performed without usage of DWB-46.
Safety assessments showed no sensitization or adverse events during the 40-day Repeat Insult Patch Test (n=107), including among subjects with sensitive skin. The four-week occlusive patch study demonstrated excellent tolerability with no clinically significant dermal irritation or adverse follicular responses observed (thus demonstrating non-comedogenicity).
Conclusion: This clinical evaluation demonstrates that DWB-P46 is safe, well-tolerated, and effective in improving visible signs of aging and skin hydration when used as monotherapy. The test article also provides effective recovery support post-procedure by enhancing and expediting skin recovery with no reports of irritation or allergy. These findings support DWB-P46 as a versatile peptide serum suitable for use across diverse skin types, including sensitive and post-treatment skin.
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