Journal of Clinical and Aesthetic Dermatology • March 2024 • Editorial Message

Welcome to the March 2024 edition of the Journal of Clinical and Aesthetic Dermatology.

We begin this issue with an original research article by Rosca et al that investigated the efficacy and safety of a topical treatment containing xyloglucan, pea proteins and Opuntia ficus-indica extracts (XPO) compared to calcipotriol 50mcg/ betamethasone 0.5mg ointment (CB). Forty-two patients diagnosed with mild-to-moderate plaque psoriasis were assigned to XPO treatment or CB for 28 days and disease status was assessed at baseline, monitored every two weeks, and at follow-up. Both groups showed a statistically significant difference in PASI score from Visit 1 to Visit 2. Authors concluded XPO showed similar efficacy to CB, significantly reducing disease severity, erythema, itching, induration, and scaling with an excellent tolerability profile.

Following this, we present a brief report by Akman-Karakaş et al that demonstrates the enhanced utility and effectiveness of the modified chalazion clamp in dermatological procedures through different cases. Though biopsies and excisions of mucosal surfaces can be challenging due to poor visualization and bleeding control, authors presented ways to utilize this device to overcome these obstacles. The authors found the modified chalazion clamp allows for better access to more distal mucosal sites for both diagnostic and therapeutic purposes and contributes controlled pressure exertion without having to readjust the screw. The authors concluded the modified chalazion clamp will be a useful tool for dentists, ear, nose and throat surgeons, gynecologists, and especially dermatologists.

Next, we present a brief report by Litaiem et al that reported two cases of Becker nevus syndrome with serious functional impairment. Data presented showed a total of two cases of patients with basal cell carcinoma that were reported in a non-photoexposed skin proximal to Becker’s nevus, and about 10 cases of melanoma developing on Becker’s nevus. Authors explained that dermatologists should be aware of this condition prompting early treatment and screening for Becker’s nevus syndrome in women and early spironolactone treatment may prevent breast hypoplasia.

Following this, we present a review article by Yousefian et al that sought to review treatment options for onychomycosis, taking into consideration the efficacy, side effect profiles, practicality of treatment, and costs to help healthcare providers offer ethically appropriate treatment regimens to their patients. A literature search was conducted using electronic and textbooks, in addition to the clinical experiences of the authors and other practitioners in treating onychomycosis. The authors determined onychomycosis has high reinfection and recurrence rates, and the treatment remains challenging as treatment selection involves ethical, evidence-based decision-making and consideration of each individual patient’s needs.

Next, we present original research by Vaidya et al that assessed the safety and effectiveness of ingredients in popular acne supplements. A comprehensive review was conducted on 13 popular supplements marketed for acne, found through a Google search. Their ingredients, prices, ratings, and existing literature on efficacy and safety were analyzed. A literature review was performed regarding the most common ingredients contained in these supplements. Authors concluded that it is crucial to exercise caution and prioritize evidence-based information when counseling patients regarding the use of acne supplements.

Following this, we present original research by Khan et al that sought to explore facets of social media usage and the effect of the COVID-19 pandemic on the acceptance of cosmetic procedures. Data showed there was a statistically significant change in the number of participants that: followed social media accounts showing results of cosmetic procedures; had thought about having a cosmetic procedure done; had discussed cosmetic procedures with a physician, dermatologist, or other professional; and believed that a cosmetic procedure would help their self-esteem.

Lastly, we present an article by Zeichner et al that evaluated antioxidant ingredients essential in the development of next-generation hyaluronic acid (HA)-based topical formulations aimed at leveraging HA’s ability to maximize anti-aging properties. Two antioxidants, glycine saponin (Glycine soja germ extract) and glycyrrhetinic acid (enoxolone), were evaluated for stimulation of endogenous HA production and inhibition of endogenous hyaluronidase activity. Authors concluded that HA included in numerous topical skin products, critical aspects of HA metabolism, especially in aging skin, have often been overlooked, including decreases in HA synthesis with increasing age.

We hope you enjoy this issue of JCAD. As always, we welcome your feedback and submissions.

Wm. Philip Werschler, MD, FAAD, FAACS—Editor-in-Chief, Aesthetic Dermatology